Preheat your oven to 400°F (200°C) and line a baking sheet with parchment paper.
In a large mixing bowl, combine the all-purpose flour, granulated sugar, baking powder, and salt. Whisk them together until evenly mixed.
Add the cold, cubed butter to the flour mixture. Using a pastry cutter or your fingertips, work the butter into the flour until it resembles coarse crumbs.
Gently fold in the fresh blueberries, being careful not to crush them.
In a separate bowl, whisk together the heavy cream and vanilla extract. Pour this mixture into the dry ingredients and stir until just combined, forming a dough.
Turn the dough out onto a floured surface and knead it gently just a few times until it comes together. Pat the dough into a circle about 1-inch thick.
Cut the circle into 8 wedges and place them on the prepared baking sheet. Brush the tops with the beaten egg and sprinkle with coarse sugar if desired.
Bake in the preheated oven for 15-20 minutes or until the scones are golden brown on top.
Remove from the oven and let cool slightly before serving. Enjoy warm or at room temperature.